Across TCGA patient cohorts, TMC3 mutation is significantly associated with the RNA expression of many other genes, with 3,181 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMC3-associated genes across cancer lineages are ELP5, TRAJ21, and RNU2-71P. Each is linked with TMC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMC3-to-partner and partner-to-TMC3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC3→partner) and Y-score (partner→TMC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ELP5 →	+0.359	+1.880	<.001	<.001	3	3
READ	TRAJ21 →	+0.689	+4.421	<.001	.009	3	3
LUAD	RNU2-71P →	+0.130	+4.122	.005	.009	3	3
UCEC	TXNL4AP1 →	+0.075	+1.262	.004	.008	3	3
UCEC	EIF5AL1 →	+0.535	+3.269	<.001	<.001	3	3
UCEC	HNRNPCP1 →	+0.428	+2.643	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,181 associations by consensus.

Exploration

TMC3 survival (RNA) · tumor vs normal (RNA) · all TMC3 data types