Across TCGA patient cohorts, TMC3 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMC3-associated genes across cancer lineages are GAPDH, Notch1, and PCNA. Each is linked with TMC3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMC3-to-partner and partner-to-TMC3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC3→partner) and Y-score (partner→TMC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.511	+2.182	.016	.033	3	3
UCEC	Notch1 →	+0.166	+1.746	<.001	.003	3	3
UCEC	PCNA →	+0.274	+1.947	<.001	<.001	3	3
UCEC	ATM →	-0.722	-1.947	<.001	<.001	3	3
COAD	Caspase-7-cleavedD198 →	+0.893	+3.169	.006	.018	3	3
UCEC	ACC1 →	+0.249	+1.064	.025	.048	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Exploration

TMC3 survival (RNA) · tumor vs normal (RNA) · all TMC3 data types