Across TCGA cell cohorts, TMC3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,605 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TMC3-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Intermembrane lipid transfer, and Protein-containing complex disassembly. Each is linked with TMC3 in more than 7 cancer types. Because this analysis shows association rather than direction, both TMC3-to-partner and partner-to-TMC3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC3→partner) and Y-score (partner→TMC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.080	+0.053	.001	.008	3	8
CNS	Intermembrane lipid transfer →	+0.053	+0.131	<.001	.003	3	7
STOMACH	Protein-containing complex disassembly →	+0.060	+0.054	<.001	.002	3	7
STOMACH	Negative regulation of myoblast fusion →	+0.101	+0.067	.008	.007	3	6
PANCREAS	Regulation of protein modification by small protein conjugation or removal →	+0.054	+0.047	<.001	.002	3	6
STOMACH	Negative regulation of calcium ion export across plasma membrane →	+0.071	+0.085	.003	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,605 associations by consensus.

Exploration

TMC3 survival (RNA) · tumor vs normal (RNA) · all TMC3 data types