Across TCGA cell cohorts, TMC3 mutation is significantly associated with the RNA expression of many other genes, with 455 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMC3-associated genes across cancer lineages are F11, C20orf85, and OR1L4. Each is linked with TMC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMC3-to-partner and partner-to-TMC3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC3→partner) and Y-score (partner→TMC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	F11 →	+0.028	+1.882	<.001	.003	3	2
SOFT_TISSUE	C20orf85 →	+0.086	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR1L4 →	+0.053	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR4D6 →	+0.035	+4.977	<.001	.002	3	1
SOFT_TISSUE	OR51L1 →	+0.027	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR51G2 →	+0.027	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 455 associations by consensus.

Exploration

TMC3 survival (RNA) · tumor vs normal (RNA) · all TMC3 data types