TMC2

Across TCGA patient cohorts, TMC2 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,642 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TMC2-associated proteins across cancer lineages are PRKAR2B, TCEAL1, and FNDC3B. Each is linked with TMC2 in more than 3 cancer types. Because this analysis shows association rather than direction, both TMC2-to-partner and partner-to-TMC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMC2 versus PRKAR2B in OV, with a Pearson correlation of 0.31.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC2→partner) and Y-score (partner→TMC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PRKAR2B →	+0.586	+0.164	.001	.005	3	4
LSCC	TCEAL1 →	+0.296	+0.229	<.001	.001	3	4
GBM	FNDC3B →	-0.544	-0.503	<.001	.001	3	4
LSCC	MAP2_S1155 →	+1.179	+0.208	<.001	<.001	3	4
LUAD	PHC3 →	+0.249	+0.143	<.001	.003	3	4
GBM	P4HB →	-0.526	-0.431	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,642 associations by consensus.

TMC2 vs PRKAR2B — OV

Explore this scatter interactively →