TMC2

Across TCGA patient cohorts, TMC2 mutation is significantly associated with the RNA expression of many other genes, with 5,490 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMC2-associated genes across cancer lineages are GFI1, KRTAP8-3P, and TRIM35. Each is linked with TMC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMC2-to-partner and partner-to-TMC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFI1 grouped by TMC2-low versus TMC2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC2→partner) and Y-score (partner→TMC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GFI1 →	+1.036	+3.348	.001	.005	3	3
LUAD	KRTAP8-3P →	+0.256	+5.339	<.001	.001	3	3
UCEC	TRIM35 →	+0.501	+1.765	<.001	<.001	3	3
COAD	TRAJ30 →	+0.656	+2.689	<.001	.008	3	3
LUSC	MIR1537 →	+0.363	+2.984	<.001	.001	3	3
READ	RPL35AP3 →	+0.697	+4.533	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,490 associations by consensus.

GFI1 by TMC2 expression — COAD

Explore this box plot interactively →