TMC2

Across TCGA patient cohorts, TMC2 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMC2-associated genes across cancer lineages are GAPDH, MEK1, and mTOR_pS2448. Each is linked with TMC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TMC2-to-partner and partner-to-TMC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by TMC2-low versus TMC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC2→partner) and Y-score (partner→TMC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.384	+1.906	.017	.014	3	2
UCEC	MEK1 →	+0.417	+1.999	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.132	-1.986	.003	.002	3	2
UCEC	NF-kB-p65_pS536 →	-0.329	-1.807	.016	.024	3	2
UCEC	p70-S6K_pT389 →	-0.139	-1.415	.015	.040	3	2
UCEC	ATM →	-0.516	-2.489	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

GAPDH by TMC2 expression — UCEC

Explore this box plot interactively →