TMC2

Across TCGA cell cohorts, TMC2 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TMC2-associated genes across cancer lineages are OR4X2, OOSP4A, and KLK3. Each is linked with TMC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMC2-to-partner and partner-to-TMC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4X2 grouped by TMC2-low versus TMC2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMC2→partner) and Y-score (partner→TMC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR4X2 →	+0.032	+5.369	<.001	.004	3	1
SOFT_TISSUE	OOSP4A →	+0.053	+4.930	<.001	.008	3	1
SKIN	KLK3 →	+0.199	+2.841	.002	.009	3	1
SKIN	APOA2 →	+0.601	+3.304	<.001	.008	3	1
SKIN	IL22RA2 →	+0.009	+2.688	.003	.008	3	1
SKIN	CD300LF →	+0.476	+2.874	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

OR4X2 by TMC2 expression — SOFT_TISSUE

Explore this box plot interactively →