TMBIM6

Across TCGA pan-cancer cohorts, TMBIM6 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TMBIM6’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TMBIM6 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TMBIM6 is over-expressed in tumor.

COAD, LSCC, and PDAC are the cancer types where TMBIM6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMBIM6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.501	<.001	8	view →
LSCC	Male	All	+0.337	<.001	6	view →
PDAC	Male	III,IV	+1.302	.001	4	view →
LUAD	All	All	+0.250	<.001	4	view →
OV	All	All	+0.844	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TMBIM6–COAD

Open the COAD breakdown →