TMBIM6

Across TCGA patient cohorts, TMBIM6 protein abundance is significantly associated with the RNA expression of many other genes, with 7,536 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible TMBIM6-associated genes across cancer lineages are COPZ1, ARF3, and MFSD5. Each is linked with TMBIM6 in more than 4 cancer types. Because this analysis shows association rather than direction, both TMBIM6-to-partner and partner-to-TMBIM6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TMBIM6 versus COPZ1 in CCRCC, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMBIM6→partner) and Y-score (partner→TMBIM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	COPZ1 →	+0.426	+0.517	<.001	<.001	3	5
OV	ARF3 →	+0.566	+0.463	<.001	<.001	3	4
OV	MFSD5 →	+0.579	+0.613	<.001	<.001	3	4
CCRCC	PRR13 →	+0.616	+0.436	<.001	.005	3	4
CCRCC	EPHA4 →	-0.899	-0.411	.001	.008	3	3
OV	TMEM106C →	+0.629	+0.400	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,536 associations by consensus.

TMBIM6 vs COPZ1 — CCRCC

Explore this scatter interactively →