TMBIM6

Across TCGA patient cohorts, TMBIM6 mutation is significantly associated with the RNA expression of many other genes, with 1,531 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMBIM6-associated genes across cancer lineages are RN7SL191P, RPSAP68, and RNA5SP419. Each is linked with TMBIM6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMBIM6-to-partner and partner-to-TMBIM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL191P grouped by TMBIM6-low versus TMBIM6-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMBIM6→partner) and Y-score (partner→TMBIM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RN7SL191P →	+1.207	+5.217	<.001	.007	3	2
COAD	RPSAP68 →	+0.099	+7.741	<.001	.009	3	2
UCEC	RNA5SP419 →	+0.926	+2.591	<.001	.004	3	2
UCEC	RNA5SP422 →	+1.325	+3.156	<.001	<.001	3	2
LUAD	POTED →	+0.018	+5.888	<.001	.002	3	1
LUAD	KCNK18 →	+0.132	+5.631	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,531 associations by consensus.

RN7SL191P by TMBIM6 expression — LUAD

Explore this box plot interactively →