TMBIM6

Across TCGA patient cohorts, TMBIM6 mutation is significantly associated with the immune_cell of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMBIM6-associated genes across cancer lineages are CD8+ T-cells, CD8+ Tcm, and CD4+ naive T-cells. Each is linked with TMBIM6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMBIM6-to-partner and partner-to-TMBIM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ T-cells grouped by TMBIM6-low versus TMBIM6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMBIM6→partner) and Y-score (partner→TMBIM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CD8+ T-cells →	+0.089	+6.142	<.001	.027	3	1
COAD	CD8+ Tcm →	+0.151	+5.917	<.001	.032	3	1
COAD	CD4+ naive T-cells →	+0.047	+6.142	<.001	.027	3	1
UCEC	Endothelial cells →	-0.042	-3.161	.027	.019	3	1
UCEC	lymphatic Endothelial cells →	-0.024	-3.405	.043	.005	3	1
UCEC	mv Endothelial cells →	-0.032	-2.947	.006	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

CD8+ T-cells by TMBIM6 expression — COAD

Explore this box plot interactively →