TMBIM6

Across TCGA cell cohorts, TMBIM6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,382 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TMBIM6-associated GO terms across cancer lineages are Endoplasmic reticulum to cytosol transport, Retrograde protein transport, ER to cytosol, and Protein exit from endoplasmic reticulum. Each is linked with TMBIM6 in more than 12 cancer types. Because this analysis shows association rather than direction, both TMBIM6-to-partner and partner-to-TMBIM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endoplasmic reticulum to cytosol transport grouped by TMBIM6-low versus TMBIM6-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMBIM6→partner) and Y-score (partner→TMBIM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Endoplasmic reticulum to cytosol transport →	+0.127	+0.594	<.001	<.001	3	13
SOFT_TISSUE	Retrograde protein transport, ER to cytosol →	+0.127	+0.594	<.001	<.001	3	13
SOFT_TISSUE	Protein exit from endoplasmic reticulum →	+0.129	+0.650	<.001	<.001	3	13
BLOOD_Leukemia	Cellular response to topologically incorrect protein →	+0.073	+0.626	<.001	<.001	3	13
SOFT_TISSUE	Vacuolar transport →	+0.062	+0.713	<.001	<.001	3	12
SOFT_TISSUE	Macroautophagy →	+0.065	+0.650	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,382 associations by consensus.

Endoplasmic reticulum to cytosol transport by TMBIM6 expression — SOFT_TISSUE

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