TMA7

Across TCGA pan-cancer cohorts, TMA7 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TMA7’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TMA7 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TMA7 is over-expressed in tumor, although a few such as HNSC and PDAC show the opposite, repressed pattern.

COAD, HNSC, and PDAC are the cancer types where TMA7 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TMA7 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+0.584	<.001	10	view →
HNSC	Male	III,IV	−1.085	<.001	8	view →
PDAC	All	All	−1.150	<.001	6	view →
LSCC	Male	II,III,IV	+0.319	.010	4	view →
CCRCC	All	All	−0.382	.009	2	view →
LUAD	All	All	+0.297	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TMA7–COAD

Open the COAD breakdown →