TMA7

Across TCGA patient cohorts, TMA7 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMA7-associated genes across cancer lineages are RNU6-542P, OR8H2, and RNU5F-6P. Each is linked with TMA7 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMA7-to-partner and partner-to-TMA7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-542P grouped by TMA7-low versus TMA7-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMA7→partner) and Y-score (partner→TMA7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-542P →	+0.436	+5.404	<.001	.005	3	2
UCEC	OR8H2 →	+0.132	+4.226	.005	.008	3	1
UCEC	RNU5F-6P →	+0.591	+4.582	<.001	.005	3	1
UCEC	RNU6-1147P →	+0.618	+3.801	<.001	.004	3	1
UCEC	RNU6-509P →	+0.404	+3.488	.007	.008	3	1
UCEC	RNU6-573P →	+0.421	+4.722	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

RNU6-542P by TMA7 expression — LUSC

Explore this box plot interactively →