Across TCGA patient cohorts, TMA16 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TMA16-associated genes across cancer lineages are A-Raf_pS299, JNK_pT183_Y185, and PKC-a. Each is linked with TMA16 in more than 1 cancer types. Because this analysis shows association rather than direction, both TMA16-to-partner and partner-to-TMA16 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMA16→partner) and Y-score (partner→TMA16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.186	-3.169	.004	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.247	-3.000	.007	.036	3	1
UCEC	PKC-a →	+0.457	+2.820	.039	.035	3	1
UCEC	VHL →	-1.178	-2.999	.001	.035	3	1
UCEC	Di-Ras3 →	-0.203	-3.169	.012	.020	3	1
UCEC	GAPDH →	+0.629	+3.169	.032	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

TMA16 survival (RNA) · tumor vs normal (RNA) · all TMA16 data types