TM9SF3

Across TCGA patient cohorts, TM9SF3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM9SF3-associated genes across cancer lineages are mTOR_pS2448, PCNA, and eEF2. Each is linked with TM9SF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM9SF3-to-partner and partner-to-TM9SF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by TM9SF3-low versus TM9SF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM9SF3→partner) and Y-score (partner→TM9SF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.136	-2.446	.011	.018	3	2
UCEC	PCNA →	+0.292	+3.459	<.001	<.001	3	2
UCEC	eEF2 →	+0.281	+2.584	.028	.010	3	1
UCEC	eIF4E →	+0.193	+3.013	.011	.018	3	1
UCEC	A-Raf_pS299 →	-0.108	-2.000	.011	.030	3	1
UCEC	ERK2 →	+0.164	+1.906	.017	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

mTOR_pS2448 by TM9SF3 expression — UCEC

Explore this box plot interactively →