TM9SF1

Across TCGA pan-cancer cohorts, TM9SF1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TM9SF1 data layer compared with 20 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TM9SF1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TM9SF1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, HNSC, and PDAC are the cancer types where TM9SF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.975	0.861	.001	20	view →
HNSC	DFS	Median	All	0.702	0.860	.007	17	view →
PDAC	OS	Quartile	All	0.422	0.248	.009	13	view →
LSCC	OS	Median	All	0.934	1.000	.007	8	view →
CCRCC	DFS	Tertile	All	0.865	1.000	.017	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TM9SF1–LUAD (DFS)

Open the LUAD breakdown →