TM9SF1

Across TCGA cell cohorts, TM9SF1 protein abundance is significantly associated with the go_rna of many other GO terms, with 1,622 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TM9SF1-associated GO terms across cancer lineages are Negative regulation of response to endoplasmic reticulum stress, Negative regulation of leukocyte activation, and Defense response to bacterium. Each is linked with TM9SF1 in more than 6 cancer types. Because this analysis shows association rather than direction, both TM9SF1-to-partner and partner-to-TM9SF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of response to endoplasmic reticulum stress grouped by TM9SF1-low versus TM9SF1-high in BONE.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TM9SF1→partner) and Y-score (partner→TM9SF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of response to endoplasmic reticulum stress →	+0.132	+1.316	.009	.004	3	7
OVARY	Negative regulation of leukocyte activation →	+0.076	+0.909	<.001	.001	3	6
LIVER	Defense response to bacterium →	+0.130	+0.810	.003	.008	2	6
CNS	Protein N-linked glycosylation →	+0.073	+1.447	<.001	.009	3	5
BONE	Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway →	+0.163	+1.552	.008	.005	3	5
LUNG_SCLC	Protein exit from endoplasmic reticulum →	+0.135	+1.061	.007	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,622 associations by consensus.

Negative regulation of response to endoplasmic reticulum stress by TM9SF1 expression — BONE

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