TM9SF1

Across TCGA cell cohorts, TM9SF1 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TM9SF1-associated genes across cancer lineages are C9orf92, SLC18A3, and TEX48. Each is linked with TM9SF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM9SF1-to-partner and partner-to-TM9SF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf92 grouped by TM9SF1-low versus TM9SF1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM9SF1→partner) and Y-score (partner→TM9SF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	C9orf92 →	+0.144	+4.369	<.001	.008	3	1
BLOOD_Leukemia	SLC18A3 →	+0.012	+3.691	<.001	.002	3	1
BLOOD_Leukemia	TEX48 →	+0.030	+3.475	<.001	.006	3	1
BLOOD_Leukemia	CCDC166 →	+0.042	+4.177	<.001	.001	3	1
BLOOD_Leukemia	DPEP2NB →	+0.057	+3.951	<.001	.005	3	1
LARGE_INTESTINE	CPO →	+0.111	+3.777	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

C9orf92 by TM9SF1 expression — SOFT_TISSUE

Explore this box plot interactively →