TM9SF1

Across TCGA cell cohorts, TM9SF1 mutation is significantly associated with the mutation status of many other genes, with 4,137 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TM9SF1-associated genes across cancer lineages are MBD6, KMT2E, and CADPS. Each is linked with TM9SF1 in more than 4 cancer types. Because this analysis shows association rather than direction, both TM9SF1-to-partner and partner-to-TM9SF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD6 grouped by TM9SF1-low versus TM9SF1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM9SF1→partner) and Y-score (partner→TM9SF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MBD6 →	+5.247	+4.429	.005	.005	1	5
LARGE_INTESTINE	KMT2E →	+1.691	+2.479	.008	.008	1	5
BLOOD_Leukemia	CADPS →	+2.662	+2.887	.005	.005	1	5
PANCREAS	ACE →	+5.115	+5.115	.005	.005	1	4
LUNG_NSCLC_LUAD	BRAT1 →	+4.187	+5.000	.008	.008	1	4
LUNG_NSCLC_LUAD	BLM →	+4.187	+5.000	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,137 associations by consensus.

MBD6 by TM9SF1 expression — BLOOD_Lymphoma

Explore this box plot interactively →