Across TCGA patient cohorts, TM6SF2 RNA expression is significantly associated with the RNA expression of many other genes, with 14,526 significant associations in total. ACC shows the largest number of these associations.

The most reproducible TM6SF2-associated genes across cancer lineages are CHRD, EFEMP2, and SCARF2. Each is linked with TM6SF2 in more than 22 cancer types. Because this analysis shows association rather than direction, both TM6SF2-to-partner and partner-to-TM6SF2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM6SF2→partner) and Y-score (partner→TM6SF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	CHRD →	+2.600	+1.165	<.001	<.001	3	23
HNSC	EFEMP2 →	+1.497	+0.487	<.001	<.001	3	23
BLCA	SCARF2 →	+1.665	+0.641	<.001	<.001	3	22
TGCT	IGDCC4 →	+1.640	+0.753	<.001	<.001	3	22
MESO	TGFB1I1 →	+1.680	+0.801	<.001	<.001	3	22
ACC	SERPINH1 →	+1.019	+0.318	<.001	.004	3	22

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,526 associations by consensus.

Exploration

TM6SF2 survival (RNA) · tumor vs normal (RNA) · all TM6SF2 data types