Across TCGA patient cohorts, TM6SF2 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,144 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TM6SF2-associated proteins across cancer lineages are THY1, TLN2, and CNPY4. Each is linked with TM6SF2 in more than 6 cancer types. Because this analysis shows association rather than direction, both TM6SF2-to-partner and partner-to-TM6SF2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (TM6SF2→partner) and Y-score (partner→TM6SF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	THY1 →	+0.752	+0.439	<.001	.001	3	7
HNSC	TLN2 →	+0.484	+0.302	<.001	<.001	3	7
BRCA	CNPY4 →	+0.396	+0.510	<.001	<.001	3	7
LSCC	COL1A1 →	+0.795	+0.307	<.001	<.001	3	7
BRCA	COL5A1 →	+0.871	+0.349	<.001	.005	3	7
OV	CRTAP →	+0.731	+0.542	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,144 associations by consensus.

Exploration

TM6SF2 survival (RNA) · tumor vs normal (RNA) · all TM6SF2 data types