Across TCGA patient cohorts, TM6SF2 mutation is significantly associated with the RNA expression of many other genes, with 493 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM6SF2-associated genes across cancer lineages are MIR4533, LINC01654, and SFXN1. Each is linked with TM6SF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM6SF2-to-partner and partner-to-TM6SF2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM6SF2→partner) and Y-score (partner→TM6SF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR4533 →	+0.339	+4.268	<.001	.008	3	2
BLCA	LINC01654 →	+0.023	+6.270	<.001	<.001	3	2
UCEC	SFXN1 →	+0.698	+2.532	<.001	.009	3	2
UCEC	TXNL1 →	+0.495	+3.234	.004	.008	3	2
UCEC	RNA5SP421 →	+1.042	+2.381	<.001	.004	3	2
UCEC	YWHAZP1 →	+0.068	+3.072	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 493 associations by consensus.

Exploration

TM6SF2 survival (RNA) · tumor vs normal (RNA) · all TM6SF2 data types