Across TCGA patient cohorts, TM6SF2 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM6SF2-associated genes across cancer lineages are Bak, eEF2, and EGFR_pY1068. Each is linked with TM6SF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM6SF2-to-partner and partner-to-TM6SF2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM6SF2→partner) and Y-score (partner→TM6SF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bak →	+0.309	+2.321	.013	.035	3	2
UCEC	eEF2 →	+0.448	+3.000	.012	.036	3	1
UCEC	EGFR_pY1068 →	-0.331	-2.321	.008	.034	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.684	+3.459	.007	.005	3	1
UCEC	IGFBP2 →	-0.796	-2.321	.014	.035	3	1
UCEC	INPP4B →	-0.361	-3.446	.026	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

TM6SF2 survival (RNA) · tumor vs normal (RNA) · all TM6SF2 data types