Across TCGA cell cohorts, TM6SF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,151 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TM6SF2-associated GO terms across cancer lineages are RNA localization, Viral process, and Positive regulation of cell-substrate adhesion. Each is linked with TM6SF2 in more than 6 cancer types. Because this analysis shows association rather than direction, both TM6SF2-to-partner and partner-to-TM6SF2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TM6SF2→partner) and Y-score (partner→TM6SF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RNA localization →	+0.071	+0.778	.001	<.001	3	7
BONE	Viral process →	+0.087	+0.651	.009	.008	3	7
BONE	Positive regulation of cell-substrate adhesion →	+0.118	+0.554	.003	.004	3	7
CNS	Regulation of transcription initiation by RNA polymerase II →	+0.051	+0.564	<.001	<.001	3	6
SKIN	Cellular response to type I interferon →	+0.086	+0.406	<.001	<.001	3	6
SKIN	Regulation of mesenchymal stem cell proliferation →	+0.159	+0.490	<.001	.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,151 associations by consensus.

Exploration

TM6SF2 survival (RNA) · tumor vs normal (RNA) · all TM6SF2 data types