TM6SF1

Across TCGA patient cohorts, TM6SF1 mutation is significantly associated with the RNA expression of many other genes, with 872 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM6SF1-associated genes across cancer lineages are ELOCP20, TRAJ11, and RNA5SP420. Each is linked with TM6SF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM6SF1-to-partner and partner-to-TM6SF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOCP20 grouped by TM6SF1-low versus TM6SF1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM6SF1→partner) and Y-score (partner→TM6SF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ELOCP20 →	+0.225	+4.594	<.001	<.001	3	2
COAD	TRAJ11 →	+1.503	+4.543	<.001	.005	3	2
UCEC	RNA5SP420 →	+0.680	+2.315	<.001	.002	3	2
SKCM	OR5K1 →	+0.022	+4.797	<.001	.003	3	2
COAD	FGF7P1 →	+0.483	+5.003	<.001	.004	3	2
UCEC	INTS4 →	+0.376	+3.724	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 872 associations by consensus.

ELOCP20 by TM6SF1 expression — SKCM

Explore this box plot interactively →