TM6SF1

Across TCGA patient cohorts, TM6SF1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM6SF1-associated genes across cancer lineages are eIF4G, JNK2, and Ku80. Each is linked with TM6SF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM6SF1-to-partner and partner-to-TM6SF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by TM6SF1-low versus TM6SF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM6SF1→partner) and Y-score (partner→TM6SF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.366	+2.459	.006	.019	3	1
UCEC	JNK2 →	+0.282	+2.469	.001	.010	3	1
UCEC	Ku80 →	+0.341	+2.128	<.001	.010	3	1
UCEC	MEK1 →	+0.350	+2.999	.028	.035	3	1
UCEC	p62 Lck ligand →	+0.410	+3.469	.003	.002	3	1
UCEC	Annexin-1 →	+0.522	+2.189	.023	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

eIF4G by TM6SF1 expression — UCEC

Explore this box plot interactively →