TM6SF1

Across TCGA cell cohorts, TM6SF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,877 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TM6SF1-associated GO terms across cancer lineages are Spermatid development, Cytoplasmic translation, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with TM6SF1 in more than 9 cancer types. Because this analysis shows association rather than direction, both TM6SF1-to-partner and partner-to-TM6SF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spermatid development grouped by TM6SF1-low versus TM6SF1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TM6SF1→partner) and Y-score (partner→TM6SF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Spermatid development →	-0.031	-0.355	.001	.004	3	10
OESOPHAGUS	Cytoplasmic translation →	+0.118	+0.942	<.001	.008	3	10
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.149	+0.960	<.001	.007	3	9
BONE	Regulation of translational initiation →	+0.078	+1.132	.001	.004	3	8
SOFT_TISSUE	Regulation of mRNA processing →	+0.116	+1.016	<.001	.007	3	8
BREAST	Post-translational protein targeting to membrane, translocation →	+0.105	+0.459	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,877 associations by consensus.

Spermatid development by TM6SF1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →