TM4SF4

Across TCGA pan-cancer cohorts, TM4SF4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TM4SF4 data layer compared with 14 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher TM4SF4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TM4SF4 expression acts as an unfavorable survival marker.

OV, LIHC, and SKCM are the cancer types where TM4SF4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.288	0.846	<.001	48	view →
LIHC	DFS	Median	All	0.043	0.543	<.001	6	view →
SKCM	OS	Median	All	0.077	0.389	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TM4SF4–OV (OS)

Open the OV breakdown →