TM4SF19

Across TCGA patient cohorts, TM4SF19 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM4SF19-associated genes across cancer lineages are Ku80, p38-MAPK_pT180_Y182, and Caspase-8. Each is linked with TM4SF19 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM4SF19-to-partner and partner-to-TM4SF19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by TM4SF19-low versus TM4SF19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM4SF19→partner) and Y-score (partner→TM4SF19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.237	+2.179	.046	.034	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.474	-2.308	.036	.036	3	2
UCEC	Caspase-8 →	-0.322	-3.143	.010	.018	3	2
UCEC	JNK2 →	+0.265	+2.834	.008	.034	3	1
UCEC	PDK1_pS241 →	+0.213	+3.169	.012	.019	3	1
UCEC	4E-BP1 →	+0.348	+2.321	.010	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Ku80 by TM4SF19 expression — UCEC

Explore this box plot interactively →