TM4SF18

Across TCGA patient cohorts, TM4SF18 mutation is significantly associated with the RNA expression of many other genes, with 81 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM4SF18-associated genes across cancer lineages are OR10A7, RNU6-172P, and TRAJ28. Each is linked with TM4SF18 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM4SF18-to-partner and partner-to-TM4SF18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10A7 grouped by TM4SF18-low versus TM4SF18-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM4SF18→partner) and Y-score (partner→TM4SF18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR10A7 →	+0.046	+5.039	<.001	.003	3	2
LUSC	RNU6-172P →	+0.462	+5.404	<.001	.005	3	2
UCEC	TRAJ28 →	+0.759	+2.717	<.001	.005	3	2
UCEC	RNU6-1213P →	+0.341	+4.654	<.001	<.001	3	2
UCEC	CES1P2 →	+0.083	+2.475	.009	.009	3	2
UCEC	ENTHD1 →	+0.208	+3.406	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

OR10A7 by TM4SF18 expression — SKCM

Explore this box plot interactively →