TM4SF18

Across TCGA patient cohorts, TM4SF18 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM4SF18-associated genes across cancer lineages are PRDX1, STAT3_pY705, and TFRC. Each is linked with TM4SF18 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM4SF18-to-partner and partner-to-TM4SF18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRDX1 grouped by TM4SF18-low versus TM4SF18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM4SF18→partner) and Y-score (partner→TM4SF18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRDX1 →	+0.251	+3.000	.035	.037	3	2
UCEC	STAT3_pY705 →	-0.497	-2.990	.001	.036	3	1
UCEC	TFRC →	+1.144	+3.000	<.001	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.273	-2.986	.005	.037	1	1
UCEC	MEK1 →	+0.469	+3.000	.026	.037	1	1
UCEC	c-Jun_pS73 →	-0.206	-3.000	.025	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PRDX1 by TM4SF18 expression — UCEC

Explore this box plot interactively →