TM4SF1

Across TCGA patient cohorts, TM4SF1 mutation is significantly associated with the RNA expression of many other genes, with 851 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM4SF1-associated genes across cancer lineages are TUBB4BP8, OR5B19P, and EME1. Each is linked with TM4SF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM4SF1-to-partner and partner-to-TM4SF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TUBB4BP8 grouped by TM4SF1-low versus TM4SF1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM4SF1→partner) and Y-score (partner→TM4SF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TUBB4BP8 →	+0.144	+4.418	<.001	.008	3	2
COAD	OR5B19P →	+0.101	+5.136	<.001	.002	3	2
UCEC	EME1 →	+0.701	+2.233	<.001	.006	3	2
UCEC	BUB1B →	+0.732	+3.467	.008	.002	3	2
UCEC	CDC45 →	+0.731	+3.475	.003	.002	3	2
LUAD	RNA5SP405 →	+0.328	+7.930	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 851 associations by consensus.

TUBB4BP8 by TM4SF1 expression — COAD

Explore this box plot interactively →