TM4SF1

Across TCGA patient cohorts, TM4SF1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM4SF1-associated genes across cancer lineages are MEK1, Shc_pY317, and eEF2. Each is linked with TM4SF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM4SF1-to-partner and partner-to-TM4SF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by TM4SF1-low versus TM4SF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM4SF1→partner) and Y-score (partner→TM4SF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.384	+2.115	.016	.019	3	2
UCEC	Shc_pY317 →	-0.184	-2.000	.005	.030	3	2
UCEC	eEF2 →	+0.470	+3.321	.002	.009	3	1
UCEC	ERK2 →	+0.202	+2.999	.016	.035	3	1
UCEC	Myosin-IIa_pS1943 →	+0.185	+2.128	.040	.010	3	1
UCEC	Notch1 →	+0.129	+2.179	.035	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

MEK1 by TM4SF1 expression — UCEC

Explore this box plot interactively →