TM4SF1

Across TCGA cell cohorts, TM4SF1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TM4SF1-associated genes across cancer lineages are NKX2-8, TPD52L3, and RTP2. Each is linked with TM4SF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM4SF1-to-partner and partner-to-TM4SF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NKX2-8 grouped by TM4SF1-low versus TM4SF1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM4SF1→partner) and Y-score (partner→TM4SF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NKX2-8 →	+0.026	+4.409	.004	.005	3	1
BLOOD_Leukemia	TPD52L3 →	+0.009	+4.539	<.001	.007	3	1
BLOOD_Leukemia	RTP2 →	+0.014	+4.539	<.001	.007	3	1
BLOOD_Leukemia	PNMA6F →	+0.022	+4.705	.003	.003	3	1
BLOOD_Leukemia	PRB4 →	+0.059	+4.276	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

NKX2-8 by TM4SF1 expression — BLOOD_Leukemia

Explore this box plot interactively →