TM4SF1-AS1

Across TCGA pan-cancer cohorts, TM4SF1-AS1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated TM4SF1-AS1 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher TM4SF1-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TM4SF1-AS1 expression acts as an unfavorable survival marker, although some lineages such as MESO and THCA show a favorable association.

BLCA, PAAD, and MESO are the cancer types where TM4SF1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.528	0.687	<.001	96	view →
PAAD	OS	Tertile	All	0.529	0.743	.001	41	view →
MESO	OS	Quartile	All	0.468	0.203	.001	26	view →
KIRC	DFS	Tertile	II,III,IV	0.402	0.651	.003	19	view →
READ	DFS	Quartile	IV	0.343	0.795	.007	19	view →
LIHC	OS	Quartile	All	0.669	0.841	.005	14	view →
ESCA	DFS	Quartile	III,IV	0.276	0.569	.003	12	view →
UCS	OS	Tertile	III,IV	0.237	0.551	.034	12	view →
UVM	DFS	Tertile	All	0.544	0.799	.032	9	view →
SARC	OS	Median	All	0.790	0.912	.007	7	view →
KIRP	DFS	Quartile	IV	0.432	0.776	.017	6	view →
LUAD	OS	Tertile	II,III,IV	0.483	0.617	.026	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

TM4SF1-AS1–BLCA (OS)

Open the BLCA breakdown →