TM2D3

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TM2D3 mutation is significantly associated with the RNA expression of many other genes, with 585 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM2D3-associated genes across cancer lineages are RPS3AP1, BNIP3, and RNA5SP426. Each is linked with TM2D3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM2D3-to-partner and partner-to-TM2D3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM2D3→partner) and Y-score (partner→TM2D3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCARPS3AP1 →+0.152+5.540<.001.00432
UCECBNIP3 →+1.023+3.593<.001.00132
LUSCRNA5SP426 →+0.318+7.924<.001.00832
UCECLINC02644 →+0.130+3.162<.001.00132
UCECRNA5SP420 →+0.805+2.552<.001.00232
UCECRNA5SP415 →+0.800+2.640<.001.00332
Each partner links to its Q-omics profile. Showing the 6 strongest of 585 associations by consensus.

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