Across TCGA patient cohorts, TM2D3 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM2D3-associated genes across cancer lineages are Heregulin, JNK2, and MEK1. Each is linked with TM2D3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM2D3-to-partner and partner-to-TM2D3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM2D3→partner) and Y-score (partner→TM2D3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.162	-2.321	.006	.034	3	1
UCEC	JNK2 →	+0.354	+3.009	<.001	.019	3	1
UCEC	MEK1 →	+0.439	+2.321	.013	.034	3	1
UCEC	Myosin-IIa_pS1943 →	+0.252	+2.472	.011	.011	3	1
UCEC	p62 Lck ligand →	+0.358	+3.179	.023	.010	3	1
UCEC	p70-S6K_pT389 →	-0.241	-3.169	.008	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

TM2D3 survival (RNA) · tumor vs normal (RNA) · all TM2D3 data types