TM2D2

Across TCGA pan-cancer cohorts, TM2D2 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TM2D2 data layer compared with 26 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher TM2D2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TM2D2 expression acts as an unfavorable survival marker.

LUSC, BLCA, and SKCM are the cancer types where TM2D2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	III,IV	0.086	0.684	<.001	12	view →
BLCA	DFS	Median	III,IV	0.083	0.572	<.001	12	view →
SKCM	OS	Median	II,III,IV	0.202	0.735	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TM2D2–LUSC (OS)

Open the LUSC breakdown →