TM2D2

Across TCGA cell cohorts, TM2D2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,455 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TM2D2-associated GO terms across cancer lineages are Regulation of macrophage fusion, Positive regulation of macrophage fusion, and Interkinetic nuclear migration. Each is linked with TM2D2 in more than 16 cancer types. Because this analysis shows association rather than direction, both TM2D2-to-partner and partner-to-TM2D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of macrophage fusion grouped by TM2D2-low versus TM2D2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TM2D2→partner) and Y-score (partner→TM2D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of macrophage fusion →	+0.252	+0.970	<.001	<.001	3	17
LUNG_SCLC	Positive regulation of macrophage fusion →	+0.252	+0.970	<.001	<.001	3	17
OVARY	Interkinetic nuclear migration →	+0.095	+0.807	.001	<.001	3	9
BLOOD_Lymphoma	Regulation of regulatory ncRNA-mediated heterochromatin formation →	+0.074	+0.594	.002	.001	3	9
LUNG_NSCLC_LUAD	Positive regulation of translational initiation →	+0.077	+0.694	<.001	.002	3	9
BREAST	Regulation of focal adhesion assembly →	+0.075	+0.922	.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,455 associations by consensus.

Regulation of macrophage fusion by TM2D2 expression — LUNG_SCLC

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