TM2D2

Across TCGA cell cohorts, TM2D2 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TM2D2-associated genes across cancer lineages are OR8B8 and OR2T11. Each is linked with TM2D2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM2D2-to-partner and partner-to-TM2D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B8 grouped by TM2D2-low versus TM2D2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM2D2→partner) and Y-score (partner→TM2D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR8B8 →	+0.022	+4.977	<.001	.007	3	1
LARGE_INTESTINE	OR2T11 →	+0.023	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

OR8B8 by TM2D2 expression — LARGE_INTESTINE

Explore this box plot interactively →