TM2D1

Across TCGA patient cohorts, TM2D1 mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TM2D1-associated genes across cancer lineages are Ku80 and AMPK_pT172. Each is linked with TM2D1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TM2D1-to-partner and partner-to-TM2D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by TM2D1-low versus TM2D1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TM2D1→partner) and Y-score (partner→TM2D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.301	+2.820	.037	.036	1	1
UCEC	AMPK_pT172 →	+0.518	+2.820	.039	.036	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Ku80 by TM2D1 expression — UCEC

Explore this box plot interactively →