TM2D1

Across TCGA cell cohorts, TM2D1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,844 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TM2D1-associated GO terms across cancer lineages are Enzyme-directed rRNA pseudouridine synthesis, Endoplasmic reticulum mannose trimming, and rRNA pseudouridine synthesis. Each is linked with TM2D1 in more than 11 cancer types. Because this analysis shows association rather than direction, both TM2D1-to-partner and partner-to-TM2D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Enzyme-directed rRNA pseudouridine synthesis grouped by TM2D1-low versus TM2D1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TM2D1→partner) and Y-score (partner→TM2D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Enzyme-directed rRNA pseudouridine synthesis →	-0.126	-0.632	.001	.005	3	12
PANCREAS	Endoplasmic reticulum mannose trimming →	+0.102	+1.113	.001	.001	3	11
BLOOD_Lymphoma	rRNA pseudouridine synthesis →	-0.122	-0.731	<.001	.001	3	10
PANCREAS	ERAD pathway →	+0.094	+1.163	<.001	<.001	3	10
URINARY_TRACT	Protein demannosylation →	+0.089	+0.925	.001	<.001	3	10
URINARY_TRACT	Protein alpha-1,2-demannosylation →	+0.089	+0.925	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,844 associations by consensus.

Enzyme-directed rRNA pseudouridine synthesis by TM2D1 expression — LUNG_SCLC

Explore this box plot interactively →