TLX3

Across TCGA patient cohorts, TLX3 RNA expression is significantly associated with the RNA expression of many other genes, with 9,449 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible TLX3-associated genes across cancer lineages are RPSAP71, FOXD3-AS1, and DLL3. Each is linked with TLX3 in more than 16 cancer types. Because this analysis shows association rather than direction, both TLX3-to-partner and partner-to-TLX3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TLX3 versus RPSAP71 in MESO, with a Pearson correlation of 0.59.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLX3→partner) and Y-score (partner→TLX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
MESO	RPSAP71 →	+1.716	+0.241	<.001	<.001	3	17
SARC	FOXD3-AS1 →	+1.494	+0.438	<.001	<.001	3	16
GBM	DLL3 →	+1.144	+0.192	.001	<.001	3	16
SARC	TROAP →	+0.843	+0.278	<.001	<.001	3	15
TGCT	INA →	+1.733	+0.618	<.001	<.001	2	16
LUSC	VAX1 →	+0.564	+0.729	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,449 associations by consensus.

TLX3 vs RPSAP71 — MESO

Explore this scatter interactively →