TLX3

Across TCGA patient cohorts, TLX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,729 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible TLX3-associated GO terms across cancer lineages are Positive regulation of cell cycle G2/M phase transition, DNA replication initiation, and Regulation of anaphase-promoting complex-dependent catabolic process. Each is linked with TLX3 in more than 15 cancer types. Because this analysis shows association rather than direction, both TLX3-to-partner and partner-to-TLX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell cycle G2/M phase transition grouped by TLX3-low versus TLX3-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TLX3→partner) and Y-score (partner→TLX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Positive regulation of cell cycle G2/M phase transition →	+0.050	+0.900	.009	.002	1	16
ESCA	DNA replication initiation →	+0.066	+1.168	.002	<.001	3	14
BRCA	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.081	+0.421	<.001	<.001	3	14
ESCA	DNA replication-dependent chromatin assembly →	+0.065	+1.248	<.001	<.001	3	14
SCLC	Microtubule depolymerization →	+0.119	+1.719	.001	.001	3	14
HNSC	Regulation of double-strand break repair via homologous recombination →	+0.026	+0.883	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,729 associations by consensus.

Positive regulation of cell cycle G2/M phase transition by TLX3 expression — ESCA

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