TLX3

Across TCGA patient cohorts, TLX3 mutation is significantly associated with the RNA expression of many other genes, with 98 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TLX3-associated genes across cancer lineages are OR7E16P, RNU6-693P, and RN7SL681P. Each is linked with TLX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLX3-to-partner and partner-to-TLX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7E16P grouped by TLX3-low versus TLX3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLX3→partner) and Y-score (partner→TLX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR7E16P →	+0.033	+4.282	<.001	.009	3	2
UCEC	RNU6-693P →	+0.226	+4.722	.001	.004	3	2
SKCM	RN7SL681P →	+0.167	+3.993	<.001	.005	3	2
BLCA	FGF7P1 →	+0.189	+7.640	<.001	.009	3	1
UCEC	MIR6075 →	+0.430	+3.638	.003	.006	3	1
LIHC	NIFKP4 →	+0.062	+4.308	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 98 associations by consensus.

OR7E16P by TLX3 expression — SKCM

Explore this box plot interactively →