TLX3

Across TCGA cell cohorts, TLX3 mutation is significantly associated with the mutation status of many other genes, with 4,349 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TLX3-associated genes across cancer lineages are TAF3, NTNG1, and GTSE1. Each is linked with TLX3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TLX3-to-partner and partner-to-TLX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAF3 grouped by TLX3-low versus TLX3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLX3→partner) and Y-score (partner→TLX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TAF3 →	+3.260	+3.498	.001	.001	1	4
LARGE_INTESTINE	NTNG1 →	+2.652	+3.471	.004	.004	1	4
BLOOD_Leukemia	GTSE1 →	+2.675	+3.080	.004	.004	1	4
BLOOD_Leukemia	GAPVD1 →	+4.845	+4.285	<.001	<.001	1	3
BLOOD_Leukemia	C15orf39 →	+4.845	+4.285	<.001	<.001	1	3
BLOOD_Leukemia	BTD →	+4.260	+4.050	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,349 associations by consensus.

TAF3 by TLX3 expression — BLOOD_Leukemia

Explore this box plot interactively →