TLX2

Across TCGA patient cohorts, TLX2 mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TLX2-associated genes across cancer lineages are RNU6-492P, OR5I1, and UTY. Each is linked with TLX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TLX2-to-partner and partner-to-TLX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-492P grouped by TLX2-low versus TLX2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TLX2→partner) and Y-score (partner→TLX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-492P →	+0.478	+7.954	<.001	.008	3	2
UCEC	OR5I1 →	+0.049	+4.226	<.001	.008	3	1
UCEC	UTY →	+0.015	+3.741	.004	.003	3	1
UCEC	OR51C1P →	+0.064	+4.420	.006	.001	3	1
UCEC	RNU6-208P →	+0.508	+3.993	.002	.001	3	1
UCEC	RNU1-31P →	+0.218	+4.335	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

RNU6-492P by TLX2 expression — HNSC

Explore this box plot interactively →