TLX2

Across TCGA cell cohorts, TLX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,958 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible TLX2-associated GO terms across cancer lineages are Regulation of myoblast fusion, Regulation of nucleotide-excision repair, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with TLX2 in more than 8 cancer types. Because this analysis shows association rather than direction, both TLX2-to-partner and partner-to-TLX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by TLX2-low versus TLX2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TLX2→partner) and Y-score (partner→TLX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of myoblast fusion →	+0.161	+1.148	<.001	<.001	3	8
OESOPHAGUS	Regulation of nucleotide-excision repair →	+0.092	+0.962	.004	.002	3	8
OESOPHAGUS	Negative regulation of syncytium formation by plasma membrane fusion →	+0.124	+0.860	<.001	<.001	3	8
OESOPHAGUS	Cytoplasmic translation →	+0.095	+0.886	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Response to starvation →	+0.051	+0.309	<.001	.009	3	8
OESOPHAGUS	Lipoprotein localization →	+0.162	+1.056	.002	.004	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,958 associations by consensus.

Regulation of myoblast fusion by TLX2 expression — OESOPHAGUS

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